In Dragon Ball GT, Piccolo makes a few brief but important appearances.
 Baby's attack
Piccolo's final farewell to Gohan before he dies.
|"Your a parasite! You've lived of my friends body's long enough! Show yourself!"— Piccolo challenging an infected Baby Gohan|
In the Baby Saga, Piccolo detects the evil presence of Baby after he possess Goten and then shows up briefly after Baby transfers bodies to Gohan. On arrival though, he is quickly blasted by the possessed Super Saiyan Gohan's Kamehameha, but survives the attack. He does not appear again until near the end of the saga when he saves a young boy who was left behind during the evacuation of Earth, as it was about to explode. When Goku returns to teleport both Piccolo and the boy away, Piccolo gives him the energy he needs to do so, but remains behind. The reason for the Earth's destruction was due to the Black Star Dragon Balls, artifacts made by Kami before he split with King Piccolo; by Piccolo's sacrifice, the Black Star Dragon Balls would be turned eternally to stone. His last moments show him having a telepathic farewell conversation with Gohan before dying again in the explosion on Earth. He does not wish to be brought back to life, so the Earth can be at peace from the Black Star Dragon Balls. He is sent to Heaven by King Yemma.
 The Ultimate Android, Super 17
|"Hahaha you fool! I am the Evil King Piccolo, and you made a mistake on sending me to the other world!"— Piccolo trying trying to convince King Yemma to send him from Heaven to Hell|
Later, in the Super 17 Saga, Piccolo starts blasting Heaven, so that King Yemma is forced to send him to Hell, where he and Dende can create a gateway between Earth and Hell that allows Goku to make it back and fight Super 17.
 The Shadow Dragons
|"I asked what are you doing here!? Please tell me you haven't died again! Do you have any idea what I had to go through to send you back to earth?"— Piccolo as he bids his final farewell to Goku|
In the final episode "Till We Meet Again", Goku goes to Hell to say good-bye, and promising to get him back into Heaven, where he rightfully belongs. Ironically, Piccolo seems to have become a protector of Hell, as we see him defeat a giant monster who was causing trouble, while the watch-keepers from Hell cheer him on.